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Wednesday, May 22, 2013

Major Cat Allergen levels in the home of patients with asthma and their relationship to sensitization to cat dander.


Introduction: Many studies have shown that dust mite and cat are the most common indoor allergies.
Allergies, in particular allergies to furry animals, increase the risk of chronic asthma and of emergency visits due to asthma attacks.

Cat allergy is very common, even for people who don’t own a cat. Previous studies have shown that cat allergen can be found in the carpets and mattresses of homes where cats are kept but also in homes where a cat has never been present.  

Research questions:
  • How much cat allergen can be found in the homes of asthmatic patients? 
  • How does having a cat affect the amount of allergen found?
  • Does the concentration of cat allergen in a home affect skin allergy tests to cats?
  • Does climate affect the amount of cat allergen found in a home?

What was done:  120 adults and children with asthma participated in the study. Participants lived in Winnipeg, Manitoba or in Vancouver, British Columbia.

Questionnaires: Participants answered questions about their asthma control, use of medication, smoking habits and asthma triggers.  They were also asked if there was a cat living in the home or if they frequently visited someone with a cat. 
Home visits: Each home was visited four times (once every season). Dust samples were collected from the bedrooms and the mattresses using a portable vacuum  cleaner and a special filter.
Skin testing: All participants were allergy tested to 11 different environmental allergens, including cats.  Skin testing was done at the beginning of the study.

Results:  90% of the children and 80% of the adults had allergies. Cat allergy was the most common allergy with 60% of the participants being allergic to cats.   Although only 15% of the homes had one or more cats, cat allergen was found in almost all (92%) of the homes. Homes with cats had the highest amount of cat allergen.
           
In Winnipeg, the amount of cat allergen found in homes without a cat was higher in winter and in spring.  In Vancouver, the amount of cat allergen in homes without a cat was the same all year round.

The amount of cat allergen was the same all year round in all homes that did have a cat.   

The incidence of cat allergy was the same for the participants that had a cat in the home as it was for participants that did not have a cat in the home.

The amount of cat allergen in the home did not seem to affect the risk of having a positive skin test to cats.

Conclusions: It is impossible to completely avoid cat allergen. A certain amount of cat allergen is present in almost all Canadian homes.

The amount of cat allergen in a home can be quite high, even if the home is cat-free. Indirect contact with a cat (visiting a friend with a cat) influences the amount of allergen found in a cat-free home. 

This may explain why so many people with asthma develop a cat allergy even if they have never had a cat.

Seasons only affect the amount of cat allergen in homes that DO NOT have a cat. High concentrations of cat allergen are present all year round if a cat lives in the home.

Having a cat free home does not seem to prevent the development of cat allergy but it does decrease the amount of cat allergen in the home. We still don’t know how much cat allergen is needed to develop a cat allergy or allergic symptoms. The amount needed to develop symptoms of asthma differs greatly from one person to another.

It is still very important for patients with asthma who are allergic to cats to minimize their exposure as much as possible.

 1995 Oct;75(4):325-30.Major cat allergen (Fel d I) levels in the homes of patients with asthma and their relationship to sensitization to cat dander. Quirce SDimich-Ward HChan HFerguson ABecker AManfreda JSimons EChan-Yeung M.

Thursday, April 25, 2013

New Educational Video now available on Youtube


The Children's Asthma Education Centre (CAEC) has developed a video to help families better understand asthma and its management. You can now view the video "Asthma Control: Pieces to the Puzzle" on Youtube. Follow the link below to view it or send it to your friends if they have a child with asthma!


http://www.youtube.com/watch?v=tmUk4DFOi0M&list=PL49-VdY5NYWmWAMjg2m_AmimkY9vVgqUa





Friday, March 1, 2013

Congratulations Dr. Becker!


               

Congratulations to Dr. Allan Becker who received the Queen Elizabeth II Diamond Jubilee commemorative Medal in February 28, 2013.

Dr. Becker is one of 60 000 deserving Canadians recognized for their contributions to CanadaDr. Becker’s work in asthma and allergy research, education and clinical practice has made significant contributions to the health of children in Manitoba, Canada and around the world.

The Chancellery of Honours, as part of the Office of the Secretary to the Governor General, administers the Queen Elizabeth II Diamond Jubilee Medal program.

Wednesday, February 27, 2013

Environment and Demographic Risk Factors for Egg Allergy

Egg allergies are one of the most common food allergies among young children.  A recent study of about five thousand infants in Australia looked at the incidence of egg allergies at twelve months of age.

Research Question: 
What are the common factors in egg allergic infants?

Findings: 
Families enrolled in the study were asked to complete a questionnaire about their child’s eating habits and reactions to eggs.  Allergy skin testing was also performed on the children.

Out of 5276 children surveyed, 873 were skin test positive to egg white.  699 underwent an egg challenge (given egg to eat in the doctor’s office to see if they had symptoms of an allergic reaction). This would help to determine who exactly had an egg allergy. 
453 of these children had confirmed egg allergy (8.6% of all children in the survey).

Researchers then looked for factors that the egg allergic children had in common.

Results:
Children were less likely to have an egg allergy at one year of age if they had older siblings and if there was a dog in the house.

Children were more likely to have an egg allergy if someone in their immediate family (parent or sibling) had allergies.

Children whose parent or parents were born in East Asia were most likely to have an egg allergy.  Although the parents themselves are less likely to have allergies, their children are more likely to have eczema and egg allergy.

Conclusion: 
Children who live with a dog and who have older siblings have a lower chance of developing egg allergy. Living with pets and older children may expose a baby to viruses and bacteria that help develop a healthy immune system. 

The childhood environment of a baby’s parents may also play a role in the child’s immune system.  In this study, children whose parents were born in East Asia were at highest risk of having an egg allergy.

Environmental and demographic risk factors for egg allergy in a population-based study of infants. Koplin JJ, Dharmage SC, Ponsonby AL, Tang ML, Lowe AJ, Gurrin LC, Osborne NJ, Martin PE, Robinson MN, Wake M, Hill DJ, Allen KJ; HealthNuts Investigators.Allergy. 2012 Nov;67(11):1415-22. doi: 10.1111/all.12015. Epub 2012 Sep 7.

Wednesday, February 13, 2013

Caesarean births and formula feeding affect infant gut bacteria.


Many babies in developed countries are born by elective caesarean section and are formula fed instead of breast-fed. This may affect the type and amount of bacteria found in a baby’s gut.

Bacteria in the gut play an important role in human health especially the developing immune system. Disruption of the gut bacteria could increase risk for diseases such as allergies and asthma.

The development of the bacteria in an infant’s gut is not yet fully understood. The first North American study, to look at the infant gut is the Canadian Health Infant Longitudinal Development (CHILD) Study, a birth cohort involving 3500 newborn infants.

Research question: 
Does being born by caesarean section affect the bacteria in the guts of babies? 
Does breast-feeding vs. bottle-feeding affect the bacteria in the guts of babies?

Findings: 
The study looked at data for 24 healthy infants. 
Of this infant sample:
·         25% were born by caesarean delivery, 75% were born vaginally
·         42% were breastfed until 4 months of age, 58% were formula fed

Fecal samples (stool) from each infant were collected at 4 months of age.
The stool was analyzed to determine the kind and amount of bacteria in the gut.  

Results:
  • Children born by c-section had a different variety of bacteria, including lower amounts of particular good bacteria.
  • Children who were formula fed had a higher amount of less desirable gut bacteria.

These differences found in the gut bacteria, may explain why infants born through caesarean delivery are at higher risk of some childhood diseases, like asthma, allergies and obesity. Breastfeeding helps protect against these diseases.

Conclusion: The method of delivery and the type of feeding can affect a child’s gut bacteria and future health. It is important to take these differences into consideration when parents and doctors make decisions about the mode of delivery for an infant and how to feed in early life.

Check out these links for more related articles.

http://www.rcinet.ca/english/daily/interviews-2012/15-39_2013-02-12-newborn-s-bacteria-differ-according-to-delivery-breastfeeding/

http://www.theglobeandmail.com/life/health-and-fitness/health/c-section-babies-missing-crucial-gut-bacteria-study-finds/article8440728/